THE INTRINSICALLY DISORDERED C-TERMINAL DOMAIN TRIGGERS NUCLEOLAR LOCALIZATION AND FUNCTION SWITCH OF PARN IN RESPONSE TO DNA DAMAGE

Poly(A)-specific ribonuclease (PARN), a multifunctional multi-domain deadenylase, is crucial to the regulation of mRNA turnover and the maturation of various non-coding RNAs.Despite extensive studies of the well-folding domains responsible for PARN catalysis, the structure and function of the C-terminal domain (CTD) remains elusive.PARN is a cytopl

Conventional switchgear such as relays and magnetic contactors (MC) continuously consume energy to maintain an open and/or closed state, contributing Hoods to unnecessary energy consumption, dissipation, and heating.The minimization of such losses has become an important topic in recent years, leading to the development of more energy-efficient tec